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<!--#endeditable--></span><h2><!--#begineditable name="当前栏目名称" action="" layout="" tpltype="" contype="" clone="" viewid="180809" contentviewid="" tagname="当前栏目名称"-->学院要闻<!--#endeditable--></h2> </div> <!--#begineditable name="文章内容" action="webber.wbst.com.news.DetailNews" layout="/system/_component/news/content/tpltitle.jsp" tpltype="1" contype="" clone="" viewid="180813" contentviewid="" tagname="文章内容"--> <script language="javascript" src="../../_dwr/interface/NewsvoteDWR.js"></script><script language="javascript" src="../../_dwr/engine.js"></script><script language="javascript" src="/system/resource/js/news/newscontent.js"></script><script type="text/javascript">NewsvoteDWR.getNewsLinkUrl(6337,'1375031859','vsb',newsSkip);function newsSkip(data){if(data != ""){window.location.href = data;}}</script><script language="javascript" src="/system/resource/js/ajax.js"></script><form name="_newscontent_fromname"><script language="javascript" src="/system/resource/js/jquery/jquery-latest.min.js"></script> <div class="TrainRightConTit"> <p> Clinical Cancer Research在线发表基础åŒÕd­¦é™¢æ¨æƒ›_ã^è¯ùN¢˜¾l„肿瘤免疫新成果</p> <span> 来源åQšåŸº¼‹€åŒÕd­¦é™? 2019-08-08 11:06:49 点击敎ͼš<script>_showDynClicks("wbnews", 1375031859, 6337)</script> ¾~–辑åQšå¼ åœ?/span> </div> <div class="TrainViewCon" id="vsb_content"><p style="text-indent: 28px; line-height: 2em; text-align: justify;"><span style="font-size: 16px">肿瘤靶向æ²È–—和免疫治疗在临床上取得了重大˜q›å±•åQŒä½†æ‚£è€…常对äÍ床各¿Uæ²»ç–—方法äñ”生抵抗。肾癌患者中大多存在着<span lang="EN-US">mTOR</span>通èµ\的异常活化和<span lang="EN-US">mTOR</span>通èµ\相关基因½Hå˜åQŒé’ˆå¯?span lang="EN-US">mTOR</span>的靶向抑制剂è¢?span lang="EN-US">FDA</span>审批通过用于æ²È–—预后不佳的肾¾l†èƒžç™Œã€?但治疗效果åƈ不理惻I¼Œä¸”患者大多发展成å¯?span lang="EN-US">mTOR</span>靶向æ²È–—的抵抗ã€?/span></p> <p style="text-indent: 28px; line-height: 2em; text-align: justify;"><span style="font-size: 16px">˜q‘æ—¥åQŒæ¨æƒ›_ã^教授团队在肿瘤领域国际知名杂志ã€?span lang="EN-US">Clinical Cancer Research</span>》在¾U¿åˆŠå‘了肄¡™Œé¶å‘æ²È–—抉|Š—机制新成果:<span lang="EN-US">TFEB mediates immune evasion and resistance to mTOR inhibition of renal cell carcinoma via induction of PD-L1</span>。该研究发现åQ?span lang="EN-US">mTOR</span>靶向抑制剂在æ²È–—è‚ùN€æ˜Ž¾l†èƒžç™Œè¿‡½E‹ä¸­èƒ½æ¿€‹z»è{录因å­?span lang="EN-US">TFEB</span>åQŒåŽè€…能诱导肿瘤¾l†èƒž<span lang="EN-US">PD-L1</span>表达从而抑åˆ?span lang="EN-US">CD8<sup>+</sup></span>¾l†èƒžçš„杀伤功能。靶å?span lang="EN-US">mTOR</span>同时联合<span lang="EN-US">PD-L1</span>抗体在小鼠模型中能显著增强对肄¡™Œæ²È–—效果。该研究ä¸ÞZÍ床联合运ç”?span lang="EN-US">mTOR</span>抑制剂和<span lang="EN-US">PD-L1</span>抗体æ²È–—æ²ÀL„ˆè‚„¡™Œæ‚£è€…提供了实验依据和理论基¼‹€ã€?/span></p> <p style="text-indent: 28px; line-height: 2em; text-align: justify;"><span style="font-size: 16px">杨想òqÏx•™æŽˆå›¢é˜Ÿåœ¨ä½“外¾l†èƒžå’ŒäÍ床肾透明¾l†èƒžç™Œç»„¾l‡ä¸­å‘现åQŒè‚¾ç™Œç»†èƒ?span lang="EN-US">TFEB</span>可正向调节免疫检查点<span lang="EN-US">PD-L1</span>æ°´åã^åQŒä¸”与äÍ床肾透明¾l†èƒžç™Œæ‚£è€…的肿瘤分çñ”和分期呈正相兟ë€?<span lang="EN-US">mTOR</span>抑制剂处理肾癌细胞系或äh原代肄¡™Œ¾l†èƒžåQŒå‡èƒ½æ˜¾è‘—上调肾癌细èƒ?span lang="EN-US">TFEB</span>å’?span lang="EN-US">PD-L1</span>æ°´åã^åQŒåœ¨è‚„¡™Œ¾l†èƒžä¸­æ•²ä½?span lang="EN-US">TFEB</span>æ°´åã^可显著阻æ–?span lang="EN-US">mTOR</span>抑制剂对<span lang="EN-US">PD-L1</span>的上调作用,说明<span lang="EN-US">mTOR</span>抑制剂可通过‹zÕdŒ–<span lang="EN-US">TFEB</span>促进<span lang="EN-US">PD-L1</span>表达。在ž®é¼ çš®ä¸‹æ¤ç˜¤æ¨¡åž‹ä¸­ï¼Œé«˜è¡¨è¾?span lang="EN-US">TFEB</span>的肾癌细胞表é?span lang="EN-US">PD-L1</span>æ°´åã^上调åQŒè¿›è€ŒæŠ‘åˆ?span lang="EN-US">CD8<sup>+</sup> T</span>¾l†èƒžæ€ä¼¤åŠŸèƒ½ç›¸å…›_ˆ†å­?span lang="EN-US">CD107a</span>åQ?span lang="EN-US">Granzyme B, IL-2 </span>å’?span lang="EN-US">TNF-‚Î</span>表达åQŒå®žçŽ°è‚¿ç˜¤å…ç–«é€ƒé€æ€»¥ä¿ƒè¿›è‚¿ç˜¤ç”Ÿé•¿ã€‚在动物模型中,<span lang="EN-US">mTOR</span>抑制剂和<span lang="EN-US">anti-PD-L1</span>联合æ²È–—能明昑֢žå¼?span lang="EN-US">CD8<sup>+</sup> T</span>淋巴¾l†èƒžçš„杀伤功能,抑制肿瘤¾l„织生长ã€?/span></p> <p style="text-indent: 28px; line-height: 2em; text-align: justify;"><span style="font-size: 16px">基础åŒÕd­¦é™¢å…ç–«å­¦¾p?span lang="EN-US">2017</span>¾U§åšå£«ç ”½I¶ç”Ÿå¼ çŒœå’ŒåŸº¼‹€åŒÕd­¦é™¢ç—…理系ŒDµäºšç¦å‰¯æ•™æŽˆä¸ø™¯¥æ–‡å…±åŒç¬¬ä¸€ä½œè€…,杨想òqÏx•™æŽˆäؓ通讯作者,该研½I¶å—到国家自然科学基金多™åšw¢ä¸Šé¡¹ç›®å’Œäººæ‰™å¹ç›®èµ„助åQŒåƈ得到协和医院泌尿外科李兵教授团队和同‹¹ŽåŒ»é™¢ç—…理科王国òqÏx•™æŽˆå¤§åŠ›æ”¯æŒã€‚该è¯ùN¢˜¾l„最˜q‘在<span lang="EN-US">mTOR</span>信号调节、肿瘤免疫微环境及免疫细胞功能调节一¾pÕdˆ—成果相ç‘ô发表åœ?span lang="EN-US">JCI,  Autophagy, Oncogene</span>以及<span lang="EN-US">Protein &Cell</span>½{‰æ‚å¿—ã€?/span></p> <p style="text-indent: 28px; line-height: 2em; text-align: justify;"><span style="font-size: 16px;"><br></span></p> <p style="text-indent: 28px; line-height: 2em; text-align: justify;"><span style="font-size: 16px;">全文链接åQ?/span><span lang="EN-US" style="font-size: 16px;">https://clincancerres.aacrjournals.org/content/early/2019/08/03/1078-0432.CCR-19-0733</span></p> <p><br></p></div> </form> <!--#endeditable--> </div> </div> </div> <script src="../../dfiles/11375/js/batxkx.js" 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